Debra Messing

1 Curtis "50 Cent" Jackson, David Dobrik 2 Maggie Gyllenhaal, Audra Fordin 3 Cara Delevingne, David Muir, Mike Holmes 4 Constance Wu, Me Ra Koh 5 Orlando Bloom, Rachael Ray 6 Ansel Elgort, Tamron Hall 7 Ashton Kutcher, Bill Skarsgård 8 Jennifer Lopez, Trisha Yearwood 9 James McAvoy, Goo Goo Dolls, Buddy Valastro 10 Kim Kardashian West, Jonathan & Drew Scott, "Science Bob" Pflugfelder 11 Taran Killam 12 Michelle Dockery 13 Sara Gilbert, the winner of "So You Think You Can Dance" 14 Live's Bread Club Week/Taraji P. Henson/Iain Armitage 15 Sylvester Stallone 16 John Goodman, Bob Iger 17 Forest Whitaker, Allison Tolman 18 Cobie Smulders, Liza Koshy 19 Patricia Heaton, Carrie Ann Inaba, Why Don't We 20 Alex Rodriguez, Brandon Micheal Hall, Steve Patterson 21 Paris Hilton, Deborah Norville 22 Rami Malek, Kristin Chenoweth, guest co-host Anderson Cooper 23 Adam Lambert, Katie Brown 24 Billy Bob Thornton, Andy Grammer 25 Penelope Cruz, Nick Kroll 26 Jenny McCarthy, Nina Dobrev 27 Jimmy Fallon, Stephen Puth 28 Clive Owen, Shaggy 29 Ted Danson, Elizabeth Olsen 30 Anne Hathaway 31 Edward Norton, Derren Brown, Vern Yip 32 Lupita Nyong'o, Alyssa Milano, Amy E. Goodman 33 Mariska Hargitay, Victoria Beckham, Catherine Fisher 34 Hailee Steinfeld, Debby Ryan, Monica Mangin 35 Michelle Pfeiffer, Julie Andrews, Monica Mangin 36 Jimmy Kimmel, Naomie Harris 37 Kate Beckinsale, Anna Camp 38 Aaron Paul, Camila Mendes 39 Willem Dafoe, Cynthia Erivo, Lindsey Stirling 40 Eddie Murphy, "Points Guy" Brian Kelly 41 Queen Latifah, Randall Park 42 Henry Golding, Bear Grylls, Sara Lynn Cauchon 43 Emilia Clarke, Harry Connick Jr. 44 Halloween show 45 Emma Thompson, Jonathan Tucker 46 Matt Czuchry, Naomi Scott, Loud Luxury, Bryce Vine 47 Tim McGraw, Bridget Moynahan 48 Kristen Stewart, Vivica A. Fox, Public 49 John Cena 50 Maura Tierney, Brian Cox 51 Helen Mirren, Kristin Davis 52 Jeff Goldblum, Ben Platt 53 Idina Menzel, Tony Hale 54 Sebastian Maniscalco 55 Anna Kendrick, Kathleen Turner, Lewis Capaldi 56 Chrissy Metz, Mat Franco 57 Steve Patterson 58 Shania Twain, Criss Angel 59 Christina Aguilera, Carrot Top 60 Howie Mandel, a performance from Cirque du Soleil's "The Beatles LOVE" 61 Garth Brooks, Drew Carey, Buddy Valastro 62 Daisy Ridley, Michael Symon 63 John Boyega, Mark Cuban, Alfred Portale 64 Scarlett Johansson, Dana Avidan Cohn 65 Laura Linney, Aaron Taylor-Johnson, Lance Ulanoff 66 Harry Hamlin, Chris Byrne 67 Jimmy Smits, Lea Michele, Monica Mangin 68 Laura Dern, Pentatonix, Monica Mangin 69 Tony Goldwyn, Brandon Routh 70 Saoirse Ronan, the new Miss Universe 71 Wilmer Valderrama, AJ Mitchell 72 Jack Black, Katie Brown, Monsta X 73 Jon Hamm, Gone West 74 Jennifer Hudson, Thomas Schumacher 75 Brie Larson, Jason Derulo, Andrea Bocelli 76 Michael B. Jordan, Paula Patton 77 Anna Kendrick, Kathleen Turner, Lewis Capaldi 78 Julia Stiles, Scott Wolf 79 Kate Bosworth, Michael Sheen, Trisha Yearwood, "Science Bob" Pflugfelder 80 Ryan Reynolds, Lacey Chabert, the Radio City Rockettes, Pentatonix 81 Shania Twain, a performance from "Le Rêve - The Dream" 82 Christina Aguilera, Blue Man Group, Carrot Top 83 Jennifer Lopez, Morris Chestnut, David Dobrik 84 Ashton Kutcher, Constance Wu, Camila Mendes, Ben Rector 85 Rose Byrne, James Holzhauer, Dr. Jen Ashton 86 Bobby Cannavale, Julian McMahon, Dr. Michael Greger 87 Penn Badgley, Jennifer Coolidge, Dr. William Li 88 Billy Porter, Dr. Taz Bhatia 89 Jason Biggs, Martin Lawrence, guest co-hosts Drew & Jonathan Scott 90 Selena Gomez, Jay Hernandez 91 Tyler Perry, Echosmith 92 Renee Zellweger, Finn Wolfhard 93 Jerry O'Connell 94 Vanessa Hudgens, Omari Hardwick 95 Daniel Radcliffe, David Alan Grier, New Hope Club 96 Tony Goldwyn, Brandon Routh 97 Blair Underwood 98 Noah Centineo, Jason George 99 "Live's End of the Year Viewers' Choice Show" 100 Bill Pullman, Jordan Fisher, Stray Kids 101 Matt Bomer 102 Antonio Banderas 103 Max Greenfield 104 Blake Lively, Little Big Town 105 Claire Danes, Derek Hough 106 Edie Falco, Peter Weber 107 Jeff Probst, Lana Condor 108 James Cromwell, Olivia Rodrigo 109 Dean Chapman 110 Kesha, Jonathan Van Ness, Maria Menounos 111 Constance Wu, Curtis "50 Cent" Jackson 112 Sam Heughan, Milo Manheim, Char Margolis 113 James Marsden, Lucy Hale, Katie Brown 114 Will Ferrell, Jerry O'Connell, Charlie Wilson 115 RuPaul, Zoey Deutch, Samantha Brown 116 The winner of the Daytona 500, Anya Taylor-Joy, "Points Guy" Brian Kelly 117 Nathan Fillion, the Impractical Jokers, Fitz and the Tantrums 118 Bob Odenkirk, Darby Stanchfield, Monica Mangin 119 Monica Mangin 120 Juliette Lewis, Josh Radnor 121 Anthony Mackie, Joseph Benavidez 122 Elisabeth Moss, Guy Fieri 123 Static & Ben El featuring Pitbull 124 Nik Wallenda, "Toy Guy" Chris Byrne 125 Winston Duke, Aaron Tveit, American Authors 126 James Taylor, Sabrina Carpenter 127 Tom Selleck 128 Richard Marx 129 Whitney Cummings, Billy Gardell 130 KJ Apa, Djimon Hounsou 131 Nick Offerman, Katherine Schwarzenegger Pratt, Barry Sonnenfeld 132 Kal Penn, Peter Weber 133 Angela Bassett, Joan Lunden, Charli D'Amerlio 134 Ariel Winter, David "Lil Dicky" Burd, New Hope Club 135 John Krasinski, Jane Levy, Goo Goo Dolls 136 Sebastian Maniscalco, Saoirse Ronan, Caitriona Balfe, Jerry O'Connell 137 Selena Gomez, RuPaul, Matt Bomer, Marc Santa Maria 138 Blake Lively, Noah Centineo, Curtis "50 Cent" Jackson, Loud Luxury with Bryce Vine 139 Tyler Perry, Scarlett Johansson, Olivia Rodrigo 140 Mark Consuelos, Carson Kressley 141 Jerry O'Connell, Isabella Boylston, James Whiteside 142 Josh Groban, Joshua Jackson 143 Kevin Bacon, Sebastian Maniscalco 144 Nicole Richie, Johnny Rzeznik 145 Issa Rae, Leslie Odom Jr. 146 Josh Radnor, Colton Underwood 147 Bethenny Frankel, MAX, Uzo Aduba 148 Michael Bublé, Kim Raver 149 Jon Cryer, Laura Prepon 150 Dr. Jennifer Asthon, Tracy Morgan, Jewel 151 Ty Burrel, Taraji P. Henson 152 Max Greenfield, Victor Rasuk, David Foster 153 Ed Helms, Alessia Cara, Jeffrey Katzenberg 154 Dove Cameron, Denise Richards, Sebastian Maniscalco 155 Whitney Cummings, Kyle Richards, Laine Hardy 156 Cate Blanchett, Aloe Blacc, Wendi McLendon-Covey 157 Rob Gronkowski, Camille Kostek, Katy Mixon 158 Pitbull, Josh Hutcherson, Science Bob 159 Natalie Dormer, Jeffrey Dean Morgan, Monica Mangin 160 Ricky Gervais, Monica Mangin 161 Andy Grammer, Mark Consuelos, Skylar Astin 162 Jane Krakowski 163 David Boreanaz, Liza Koshy 164 Lionel Richie, Katy Perry, Luke Bryan 165 Jimmy Kimmel, Beth Behrs 166 Bethenny Frankel, Michael Bublé, Jewel 167 Mandy Moore 168 Christina Applegate, Jason Mraz 169 Dua Lipa 170 Mila Kunis, Ashton Kutcher, Hilarie Burton Morgan 171 Lin-Manuel Miranda, Phil Donahue, Marlo Thomas 172 Daniel Radcliffe, Melinda Macht-Greenberg 173 Michelle Dockery, Lance Ulanoff 174 James Marsden, Farnoosh Torabi 175 Yara Shahidi, Daveed Digga, Dr. Jennifer Ashton 176 Glenn Close 177 Laura Linney, Just Sam 178 Debi Mazar 179 Darren Criss 180 Debra Messing 181 Steve Patterson 182 Mark Consuelos, Leann Rimes, David Spade 183 Madison Beer, Keegan-Michael Key 184 Josh Gad 185 Tracee Ellis Ross 186 Addison Rae, AJR, DJ Pauly D 187 Amanda Peet 188 David Muir 189 Carson Kressley 190 Blair Underwood 191 Derek Luke 192 Josh Duhamel 193 Anderson Cooper, Jean Chatzky 194 Jude Apatow 195 Steve Buscemi 196 Andy Cohen 197 Kevin Costner, Sofia Carson 198 Padma Lakshmi, Matt Bomer 199 Laverne Cox 200 Bryce Dallas Howard 201 Avril Lavigne, Lonnie Chavis 202 John Lithgow 203 Mark Consuelos, Josh Hutcherson, Pitbull 204 Laura Linney, Mark Consuelos, Rob Gronkowski & Camille 205 Ricky Gervais, Taraji P. Henson 206 Mandy Moore, Issa Rae, Laura Prepon 207 Tamron Hall 208 Christina Applegate, Leslie Odom Jr., Liza Koshy 209 Lin-Manuel Miranda, Whitney Cummings, Jason Mraz 210 Ashton Kutcher, Mila Kunis, Sebastian Maniscalco 211 Renée Elise Goldsberry 212 Rob Lowe 213 Mandy Moore, Buddy Valastro 214 Adam Scott, Gabby Barrett, Val Chmerkovsky and Jenna 215 Regina Hall, Gabby Barrett 216 Live’s I in I Do Week 217 Luke Bryan 218 Christopher Jackson 219 Dakota Fanning 220 Camila Mendes 221 Maria Shriver, Patrick Schwarzenegger 222 Andy Cohen 223 Tony Hale 224 Jane Curtin 225 Nia Long 226 Lisa Rinna 227 Kiefer Sutherland, Michael Symon 228 Christopher Meloni 229 Katie Holmes, Ron Howard 230 Eva Larue, NASA Astronauts 231 Regis Farewell Celebration Encore 232 Katie Lowes, Jai Courtney 233 Katie Lowes, Jordan Fisher 234 Maria Menounos, Derek Hough 235 Howie Mandel, Maria Menounos 236 Elaine Welteroth, Common 237 Liza Koshy, Julie Chen, Shaggy 238 Sisanie, Bryan Cranston 239 Sisanie, Joe Manganiello 240 Jake Johnson, Marissa Mullen 241 Maria Shriver, Patrick Schwarzenegger, Christopher Jackson 242 Bear Grylls, Science Bob 243 Glenn Close, Yara Shahidi 244 Caroline Rhea, Daveed Diggs, Debra Messing 245 Debi Mazar, Keegan-Michael Key, Madison Beer 246 Tracee Ellis Ross, Josh Duhamel, Carson Kressley, Michelle Dockery 247 Joseph Gordon-Levitt 248 Sofia Carson, John Lithgow, Laverne Cox 249 Matt Bomer, Connie Britton, Lonnie Chavis 250 Rob Lowe, Padma Lakshmi, Judd Apatow 251 Regina Hall, Adam Scott, Avril Lavigne 252 Kristin Chenoweth 253 Tamron Hall, Dakota Fanning 254 Luke Bryan, Camila Mendes, Steve Buscemi 255 Lisa Rinna, Nia Long, Natasha Bedingfield